Obesity is a complex medical condition influenced by various factors, including genetics, environment, and lifestyle. Various aspects of food consumption, appetite and satiety are linked to abnormalities in brain circuits and hormones. These include hormones like Ghrelin which stimulate hunger, and others like GLP-1, Cholecystokinin, Leptin and Amylin, which leads to satiety. So despite our efforts to control the intake of high-calorie food and exercise, it is essential to address the various abnormal physiological changes that drive obesity. While making healthy choices is vital, it is not as simple as “trying harder” or having more willpower.